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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakata, Tsuneari | 1B | Duluth Sea Gulls | 31 | 05/29/2020 | Fukuyama | JPN | Left | Right | 6' 1" | 200 lbs | $4,452,000 |
| Sakuma, Noriyuki | CL | Detroit Thunderbirds | 34 | 05/11/2017 | Kyoto | JPN | Right | Right | 6' 2" | 195 lbs | $17,600,000 |
| Sandoval, Cristo | SS | Chicago Architects | 17 | 07/21/2034 | Ensenada | MEX | Right | Right | 6' 2" | 165 lbs | - |
| Sandoval, Héctor | SP | Traverse City Bears | 17 | 03/11/2035 | Ponce | PUR | Left | Right | 6' 0" | 170 lbs | - |
| Santana, Pedro | SS | Toledo Neptunes | 17 | 06/03/2034 | Cevicos | DOM | Left | Right | 6' 2" | 175 lbs | - |
| Santiago, Francisco | SP | Owen Sound Waveriders | 17 | 05/14/2034 | Güines | CUB | Right | Right | 6' 11" | 225 lbs | - |
| Santiago, Jorge | SP | Windsor Vigilantes | 17 | 06/09/2034 | Managua | NCA | Right | Right | 6' 6" | 190 lbs | - |
| Santiago, Miguel | LF | Kingston Comets | 35 | 11/08/2016 | Esperanza | DOM | Left | Left | 6' 6" | 235 lbs | $507,500 |
| Sapiara, Luis Manuel | SP | Hamilton Mounties | 17 | 04/25/2034 | La Guaira | VEN | Right | Right | 6' 2" | 175 lbs | - |
| Schurman, Herb | LF | Hamilton Mounties | 27 | 02/09/2025 | Simcoe | CAN | Right | Right | 6' 1" | 195 lbs | $1,750,000 |
| Scott, Dave | SP | Toledo Neptunes | 31 | 08/30/2020 | Cleveland | USA | Left | Left | 6' 0" | 200 lbs | $4,914,800 |
| Segura, Koert | SP | Chicago Architects | 16 | 06/02/2035 | Santa Cruz | ARU | Right | Right | 6' 6" | 195 lbs | - |
| Sellek, Jayden | RP | Duluth Sea Gulls | 17 | 03/02/2035 | Sint Nicolas | ARU | Right | Right | 6' 0" | 165 lbs | - |
| Sepúlveda, Robinson | SP | Thunder Bay Caribou | 18 | 02/20/2034 | Las Tunas | CUB | Right | Right | 6' 4" | 185 lbs | - |
| Shannon, Ken | RP | Windsor Vigilantes | 37 | 02/26/2015 | Detroit | USA | Right | Right | 6' 3" | 200 lbs | $4,640,000 |
| Siew, Xiao-gang | CL | Chicago Architects | 17 | 07/04/2034 | Taipei | TPE | Left | Left | 6' 11" | 215 lbs | - |
| Simms, Sam | 3B | Milwaukee Eagles | 27 | 10/31/2024 | Scottsbluff | USA | Right | Right | 6' 0" | 200 lbs | $507,500 |
| Simonin, Kevin | SP | Thunder Bay Caribou | 29 | 05/18/2022 | Holland | CAN | Right | Right | 6' 3" | 200 lbs | $14,400,000 |
| Simpson, Cliff | SP | Windsor Vigilantes | 30 | 06/06/2021 | Calumet | USA | Left | Left | 6' 6" | 195 lbs | $19,000,000 |
| Skeffington, Patrick | 1B | Kingston Comets | 25 | 09/23/2026 | St. Paul | USA | Right | Right | 6' 3" | 205 lbs | $507,500 |
| Smart, Hervé | RP | Toronto Maples | 32 | 10/04/2019 | Holland | CAN | Right | Right | 6' 2" | 200 lbs | $1,995,000 |
| Smithers, Robbie | RP | Duluth Sea Gulls | 17 | 04/13/2035 | Oranjestad | ARU | Switch | Left | 6' 3" | 180 lbs | - |
| Sokhakian, Harvey | RP | Kingston Comets | 28 | 06/18/2023 | Pontiac | USA | Right | Right | 6' 8" | 215 lbs | $2,375,000 |
| Sosa, Alberto | C | Traverse City Bears | 17 | 04/26/2034 | Mexico City | MEX | Right | Right | 6' 1" | 195 lbs | - |
| Soto, Armando | 1B | Free Agent | 29 | 12/13/2022 | Waterford Township | USA | Left | Left | 6' 0" | 200 lbs | - |
| Stoddart, Bernie | 1B | Traverse City Bears | 31 | 07/27/2020 | Holland | CAN | Left | Left | 6' 4" | 195 lbs | $12,000,000 |
| Stott, Larry | RP | Chicago Architects | 24 | 09/07/2027 | London | CAN | Right | Right | 6' 2" | 200 lbs | $507,500 |
| Stout, Alan | SS | Detroit Thunderbirds | 23 | 06/24/2028 | Fremont | USA | Switch | Right | 6' 2" | 185 lbs | $507,500 |
| Sutkamp, Addie | SP | Owen Sound Waveriders | 17 | 09/28/2034 | Meerlo-Wanssum | NED | Right | Right | 6' 8" | 205 lbs | - |
| Suzuki, Takeru | RP | Duluth Sea Gulls | 16 | 04/30/2035 | Okayama | JPN | Left | Left | 6' 1" | 175 lbs | - |
| Suárez, Jaime | RP | Free Agent | 17 | 01/24/2035 | Pinar del Rio | CUB | Left | Left | 5' 10" | 155 lbs | - |
| Suárez, Miguel | C | Free Agent | 38 | 02/20/2014 | San Juan | PUR | Left | Right | 6' 0" | 200 lbs | - |
| Sweet, Arlen | RP | Detroit Thunderbirds | 28 | 08/30/2023 | Lincoln | USA | Right | Right | 5' 10" | 190 lbs | $2,500,000 |
| Sánchez, Anastasio | SP | Toledo Neptunes | 18 | 12/20/2033 | Río Grande | PUR | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Juan | RP | Free Agent | 38 | 12/21/2013 | Greentown | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sánchez, Luis Antonio | RP | Toronto Maples | 17 | 05/08/2034 | Neyba | DOM | Left | Left | 6' 2" | 175 lbs | - |
| Sánchez, Manuel | SP | Kingston Comets | 17 | 03/15/2035 | Cabudare | VEN | Right | Left | 6' 3" | 190 lbs | - |
